Dynamic range defines which of the following?

• A. The concentration range over which the assay provides accurate and precise results
• B. The range of instrument temperatures
• C. The number of operators who can run the assay
• D. The time window of sample stability

Answer: (D)

Dynamic range is the span of analyte concentrations over which an assay yields results that are accurate and precise. Within this range the analytical response is reliable and meets predefined quality criteria, typically defined by a calibration curve and acceptable accuracy and precision. The range is bounded at the low end by the limit of quantitation or detection and at the high end by loss of linearity or signal saturation. Therefore, the description that matches is the concentration range over which the assay provides accurate and precise results. The other choices refer to instrument temperature limits, staffing, or sample stability windows, which do not define dynamic range.